|Born||Edward Lawrie Tatum
December 14, 1909
Boulder, Colorado, United States
|Died||November 5, 1975
New York City, United States
|Alma mater||University of Chicago
University of Wisconsinâ€“Madison
|Notable students||Esther M. Lederberg|
|Known for||Gene regulation of biochemical events within cells|
|Notable awards||Nobel Prize in Physiology or Medicine|
In microbiology the roles of mutation and selection in evolution are coming to be better understood through the use of bacterial cultures of mutant strains.
As has repeatedly been stated, the underlying hypothesis, which in a number of cases has been supported by direct experimental evidence, is that each gene controls the production, function, and specificity of a particular enzyme.
That the primary effect of gene mutation may be as simple as the substitution of a single amino acid by another and may lead to profound secondary changes in protein structure and properties has recently been strongly indicated by the work of Ingram on hemoglobin.